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Article

Enhancement of cisplatin sensitivity in Lewis Lung carcinoma by liposome-mediated delivery of a survivin mutant.

Journal of experimental & clinical cancer research : CR - 12 May 2010

Yu Dan-Dan, Wang Chun-Ting, Shi Hua-Shan, Li Zhi-Yong, Pan Li, Yuan Qing-Zhong, Leng Fei, Wen Yuan, Chen Xiang, Wei Yu-Quan

Abstract excerpt

BACKGROUND: A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin expression or function may lead to tumor sensitization to chemical and physical agents. The aim of this study was to determine whether a dominant-negative mouse survivin mutant could enhance the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20462440
DOI: 10.1186/1756-9966-29-46
PMCID: PMC2878293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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