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Issues and updates: evaluating estrogen receptor-alpha, progesterone receptor, and HER2 in breast cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2010

Allred D Craig

Abstract excerpt

There are currently three prognostic/predictive biomarkers used in routine clinical management of patients with breast cancer, and their assessment is mandatory. They include estrogen receptor-alpha (ERalpha), progesterone receptor (PgR), and the HER2 oncogene/oncoprotein. This paper briefly reviews the assessment of ERalpha, PgR, and HER2 in breast cancer, emphasizing recent progress and persistent controversies.

Topics

Biomarkers, Tumor
Breast Neoplasms
Estrogen Receptor alpha
Female
Genes, erbB-2
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Receptor, ErbB-2
Receptors, Progesterone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20436503
DOI: 10.1038/modpathol.2010.55

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