Article
Identity-by-descent matrix decomposition using latent ancestral allele models.
Genetics - 1 Jul 2010
ter Braak Cajo J F, Boer Martin P, Totir L Radu, Winkler Christopher R, Smith Oscar S, Bink Marco C A M
Abstract excerpt
Genetic linkage and association studies are empowered by proper modeling of relatedness among individuals. Such relatedness can be inferred from marker and/or pedigree information. In this study, the genetic relatedness among n inbred individuals at a particular locus is expressed as an n x n square matrix Q. The elements of Q are identity-by-descent probabilities, that is, probabilities that two individuals...
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