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Article

Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults.

Physiological genomics - 7 Jul 2010

Iemitsu Motoyuki, Murakami Haruka, Sanada Kiyoshi, Yamamoto Kenta, Kawano Hiroshi, Gando Yuko, Miyachi Motohiko

Abstract excerpt

The TT genotype of C677T polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR) induces elevation of homocysteine level and leads to atherosclerosis and arterial stiffening. Furthermore, cardiorespiratory fitness level is also associated with arterial stiffness. In the present study, a cross-sectional investigation of 763 Japanese men and women (18-70 yr old) was performed to clarify the effects of...

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Share to Adolescent
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carotid Arteries

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 20406848
DOI: 10.1152/physiolgenomics.00039.2010

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults.PMID 20406848Read ↗

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PPARγ2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness.Semantic proximity Read ↗

Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism.Semantic proximity Read ↗

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