Article
Similar phenotype characteristics comparing familial and sporadic premature ovarian failure.
Menopause (New York, N.Y.) - 1 Jul 2010
Janse Femi, Knauff Erik A H, Niermeijer Martinus F, Eijkemans Marinus J, Laven Joop S E, Lambalk Cornelius B, Fauser Bart C J M, Goverde Angelique J
Abstract excerpt
OBJECTIVE: Premature ovarian failure (POF) is characterized by secondary amenorrhea before the age of 40 years, along with repeated increased follicle-stimulating hormone and low estrogen concentrations. POF is considered a complex genetic disease with a familial presentation in 12% to 50% of cases. POF may originate from different genes and various gene-environment interactions. The aim of this study was to...
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