Article
Heterogeneity of pulmonary perfusion as a mechanistic image-based phenotype in emphysema susceptible smokers.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010
Alford Sara K, van Beek Edwin J R, McLennan Geoffrey, Hoffman Eric A
Abstract excerpt
Recent evidence suggests that endothelial dysfunction and pathology of pulmonary vascular responses may serve as a precursor to smoking-associated emphysema. Although it is known that emphysematous destruction leads to vasculature changes, less is known about early regional vascular dysfunction which may contribute to and precede emphysematous changes. We sought to test the hypothesis, via multidetector row CT...
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