Article
Gastrointestinal stromal tumor with two genetic abnormalities on different alleles: report of a case.
Surgery today - 1 Mar 2010
Ichikawa Yasushi, Miyagi Yohei, Fujii Shoichi, Ota Mitsuyoshi, Yamagishi Shigeru, Hasegawa Shingo, Saito Shuuji, Ike Hideyuki, Ohki Shigeo, Nakano Akira, Matsumura Naomi, Ishikawa Takashi, Kunizaki Chikara, Shimada Hiroshi
Abstract excerpt
We report a case of a gastrointestinal stromal tumor (GIST) with strong and faint KIT protein staining, respectively, at two different sites. A single point mutation (c1727 T>C) was detected in DNA extracted from both sites, and a further deletion mutation (c1678_1680 del GTT) was detected in DNA...
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