Article
Severe retinopathy of prematurity associated with FZD4 mutations.
Ophthalmic genetics - 1 Mar 2010
Ells Anna, Guernsey Duane L, Wallace Karin, Zheng Binyou, Vincer Michael, Allen Alexander, Ingram April, DaSilva Orlando, Siebert Lee, Sheidow Thomas, Beis Jill, Robitaille Johane M
Abstract excerpt
PURPOSE: To determine whether mutations in the FZD4 gene are a risk factor for developing severe ROP. METHODS: Three Canadian tertiary care centers recruited premature infants prospectively and retrospectively, and assigned affectation status based on the maximum degree of severity of ROP recorded in both eyes. Mutation screening of the FZD4 gene was performed using direct sequencing. All sequence changes were...
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