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What next for preimplantation genetic screening (PGS)? A position statement from the ESHRE PGD Consortium steering committee

2 Feb 2010

Abstract excerpt

Since 2004, there have been 11 randomized controlled trials (RCTs) mainly for advanced maternal age (AMA), which have shown no benefit of performing preimplantation genetic screening (PGS). Ten of the RCTs have been performed at the cleavage stage and one at the blastocyst stage. It is probable that the high levels of chromosomal mosaicism at cleavage stages, which may result in the tested cell not being...

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PMID: 20124394
DOI: 10.1093/humrep/dep476

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