Article
The rate of establishment of complex adaptations.
Molecular biology and evolution - 1 Jun 2010
Lynch Michael, Abegg Adam
Abstract excerpt
A central problem in evolutionary theory concerns the mechanisms by which adaptations requiring multiple mutations emerge in natural populations. We develop a series of expressions that clarify the scaling of the time to establishment of complex adaptations with population size, mutation rate, magnitude of the selective disadvantage of intermediate-state alleles, and the complexity of the adaptation. In general,...
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