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Article

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.

Journal of clinical pharmacology - 1 Apr 2010

Borges Silvana, Desta Zeruesenay, Jin Yan, Faouzi Azzouz, Robarge Jason D, Philips Sanosh, Philip Santosh, Nguyen Anne, Stearns Vered, Hayes Daniel, Rae James M, Skaar Todd C, Flockhart David A, Li Lang

Abstract excerpt

Accurate assessment of CYP2D6 phenotypes from genotype is inadequate in patients taking CYP2D6 substrate together with CYP2D6 inhibitors. A novel CYP2D6 scoring system is proposed that incorporates the impact of concomitant medications with the genotype in calculating the CYP2D6 activity score. Training (n = 159) and validation (n = 81) data sets were obtained from a prospective cohort tamoxifen pharmacogenetics...

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Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Breast Neoplasms
Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Activation

Predictive Value of Tests

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PMID: 20081063
DOI: 10.1177/0091270009359182
PMCID: PMC3816977

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