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Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin

8 Oct 2009

Abstract excerpt

Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isolated human bulge cells, characterized as CD200+/KRT15+/KRT19+ cells of the HF, by...

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PMID: 20050020
DOI: 10.1111/j.1474-9726.2009.00526.x

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