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Combined QF‐PCR and MLPA molecular analysis of miscarriage products: an efficient and robust alternative to karyotype analysis

18 Dec 2009

Abstract excerpt

OBJECTIVES: To replace G-banded chromosome analysis for miscarriage products with a combined molecular approach: QF-PCR and MLPA, to increase efficiency, reduce costs, and improve the diagnostic success rate for these samples. METHODS: A review of 10 years of karyotype results for miscarriages products indicated that 2.7% of nonmosaic chromosome imbalance would not be detected by the molecular approach. The...

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Share to Genomic variations and chromosomal abnormalities
Share to Prenatal Screening and Diagnostics
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PMID: 20024950
DOI: 10.1002/pd.2424

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