Article
Consanguinity sans reproche.
Human genetics - 1 Jan 1991
Ten Kate L P, Scheffer H, Cornel M C, van Lookeren Campagne J G
Abstract excerpt
In a family with two cystic fibrosis (CF) patients and consanguineous parents, DNA analysis showed that the CF in the children was not caused by homozygosity by descent, since two different mutations were involved. A formula is given for calculating the probability that parental consanguinity, if it exists, is causally related to the existence of an autosomal recessive disease in affected children.
Topics
- Alleles
- Consanguinity
- Cystic Fibrosis
- Female
- Humans
- Male
- Models, Genetic
- Mutation
- Pedigree
- Probability