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Article

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

22 Nov 2009

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19966810
DOI: 10.1038/nm.2063

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Related research

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A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndromePMID 19966810Read ↗

New insights into 5q- syndrome as a ribosomopathySemantic proximity Read ↗

RECENT ADVANCES IN THE 5Q- SYNDROMESemantic proximity Read ↗

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humansSemantic proximity Read ↗

A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure.Semantic proximity Read ↗

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research toolSemantic proximity Read ↗

Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in miceSemantic proximity Read ↗

Common deleted genes in the 5q− syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null miceSemantic proximity Read ↗

The 5q deletion size in myeloid malignancies is correlated to additional chromosomal aberrations and to TP53 mutations.Semantic proximity Read ↗

The role of p53 in developmental syndromesSemantic proximity Read ↗

Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to replication error phenotypeSemantic proximity Read ↗

Mouse chromosome 5.Semantic proximity Read ↗

Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q− syndromeSemantic proximity Read ↗

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