Article
13C NMR evidence that substitution of glutamine for arginine 3500 in familial defective apolipoprotein B-100 disrupts the conformation of the receptor-binding domain.
The Journal of biological chemistry - 15 Feb 1991
Lund-Katz S, Innerarity T L, Arnold K S, Curtiss L K, Phillips M C
Abstract excerpt
Familial defective apoB-100 is a genetic mutation that is characterized by abnormal low density lipoprotein (LDL) and moderate hypercholesterolemia. Heterozygotes for this disorder possess two populations of LDL. One has normal receptor binding, and the other, which can be isolated by monoclonal...
Topics
- Apolipoprotein B-100
- Apolipoproteins B
- Arginine
- Circular Dichroism
- Glutamine
- Heterozygote
- Humans
- Magnetic Resonance Spectroscopy
- Mutation
- Protein Conformation
- Spectrophotometry, Ultraviolet