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Article

Genetic evaluation and management of fetal chylothorax: review and insights from a case of Noonan syndrome.

Lymphology - 1 Sept 2009

Chen C H, Chen T H, Kuo S J, Chen C P, Lee D J, Ke Y Y, Yeh K T, Ma G C, Liu C S, Shih J C, Chen M

Abstract excerpt

Fetal chylothorax is one of a very few syndromes that can be treated in utero with thoracoamniotic shunting or pleurodesis by OK-432 as two major therapeutic modalities. We report on a fetus with Noonan syndrome and a missense mutation c.182A > C (p.Asp61Ala) of PTPN11 who responded poorly to antenatal pleurodesis by OK-432. Based on our previous publication and this case study, we propose that fetal chylothorax...

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Share to Fetal Death
Share to PTPN11 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

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Share to Ultrasonography, Prenatal

Source

Identifiers

PMID: 19927903

Genes

PTPN11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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