Article
Normal spermatogenesis in a man with mutant luteinizing hormone.
The New England journal of medicine - 5 Nov 2009
Achard Caroline, Courtillot Carine, Lahuna Olivier, Méduri Géri, Soufir Jean-Claude, Lière Philippe, Bachelot Anne, Benyounes Hassani, Schumacher Michael, Kuttenn Frédérique, Touraine Philippe, Misrahi Micheline
Abstract excerpt
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells. We report a mutation in LHB in a man and his sister. The man presented with absence of virilization, undetectable luteinizing hormone, and a low serum testosterone level. He had complete spermatogenesis with a normal sperm count. The mutant luteinizing hormone had a...
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