Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.

doi:10.1038/jid.2009.281

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Article

Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.

The Journal of investigative dermatology - 1 Mar 2010

Bodemer Christine, Hermine Olivier, Palmérini Fabienne, Yang Ying, Grandpeix-Guyodo Catherine, Leventhal Phillip S, Hadj-Rabia Smail, Nasca Laurent, Georgin-Lavialle Sophie, Cohen-Akenine Annick, Launay Jean-Marie, Barete Stéphane, Feger Frédéric, Arock Michel, Catteau Benoît, Sans Beatrix, Stalder Jean François, Skowron Francois, Thomas Luc, Lorette Gérard, Plantin Patrice, Bordigoni Pierre, Lortholary Olivier, de Prost Yves, Moussy Alain, Sobol Hagay, Dubreuil Patrice

Abstract excerpt

Adult mastocytosis is an incurable clonal disease associated with c-KIT mutations, mostly in exon 17 (D816V). In contrast, pediatric mastocytosis often spontaneously regresses and is considered a reactive disease. Previous studies on childhood mastocytosis assessed only a few patients and focused...

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PMID: 19865100
DOI: 10.1038/jid.2009.281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19865100-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

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