Article
Family studies in von Willebrand's disease by analysis of restriction fragment length polymorphisms and an intragenic variable number tandem repeat (VNTR) sequence.
British journal of haematology - 1 Oct 1990
Standen G R, Bignell P, Bowen D J, Peake I R, Bloom A L
Abstract excerpt
We have previously identified a microsatellite variable number tandem repeat region of the nucleotide sequence ATCT within intron 40 of the von Willebrand factor (vWF) gene. By polymerase chain reaction (PCR) amplification of this region, eight major alleles have been demonstrated in the South Wales population, with an overall heterozygosity rate of 75%. Direct sequencing has shown that the alleles correspond to...
Topics
- Base Sequence
- DNA
- Female
- Humans
- Introns
- Male
- Molecular Sequence Data
- Oligonucleotide Probes
- Pedigree
- Phenotype
- Polymorphism, Restriction Fragment Length