Article
Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.
Science (New York, N.Y.) - 21 Dec 1990
Vnencak-Jones C L, Phillips J A
Abstract excerpt
Familial growth hormone deficiency type 1A is an autosomal recessive disease caused by deletion of both growth hormone-1 (GH1) alleles. Ten patients from heterogeneous geographic origins showed differences in restriction fragment length polymorphism haplotypes in nondeleted regions that flanked G...
Topics
- Alleles
- Base Composition
- Base Sequence
- Chromosome Deletion
- Crossing Over, Genetic
- DNA
- Deoxyribonuclease EcoRI
- Growth Hormone
- Haplotypes
- Humans
- Molecular Sequence Data
- Oligonucleotide Probes
- Polymorphism, Restriction Fragment Length
- Repetitive Sequences, Nucleic Acid
- Restriction Mapping
- Sequence Homology, Nucleic Acid
- Transcription, Genetic