Article
Mae III positively detects the mitochondrial mutation associated with type I Leber's hereditary optic neuropathy.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Oct 1990
Stone E M, Coppinger J M, Kardon R H, Donelson J
Abstract excerpt
Leber's hereditary optic neuropathy is a blinding disease that usually causes acute or subacute central visual loss in adolescent and young adult males. In patients who lack a family history of a similar illness, Leber's disease has been a diagnosis of exclusion. The recent discovery of a specifi...
Topics
- Adult
- Base Sequence
- DNA, Mitochondrial
- Deoxyribonucleases, Type II Site-Specific
- Electrophoresis, Polyacrylamide Gel
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Optic Atrophies, Hereditary
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Visual Acuity