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Article

An infrequent DNA polymorphism associated with severe von Willebrand's disease.

British journal of haematology - 1 May 1990

Caekebeke-Peerlinck K M, Bakker E, Briet E

Abstract excerpt

Genomic DNA of six unrelated Dutch patients with severe von Willebrand's disease (vWD) was submitted to restriction fragment length polymorphism analysis. We observed a strong association between a 36 kb allele detected by a partial complementary DNA probe (pvWF 1100) and the restriction enzyme XbaI with severe von Willebrand's disease. This 36 kb allele is rare (allele frequency of 7%) both in the general...

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Identifiers

PMID: 1973902
DOI: 10.1111/j.1365-2141.1990.tb02619.x

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