Article
Additional deletion in sex-determining region of human Y chromosome resolves paradox of X,t(Y;22) female.
Nature - 19 Jul 1990
Page D C, Fisher E M, McGillivray B, Brown L G
Abstract excerpt
Whether a human embryo develops as a male or a female is determined by the presence of the Y chromosome. The sex-determining function lies entirely in interval 1A, inasmuch as most XX individuals with descended testes and normal male external genitalia carry this small region of the Y chromosome....
Topics
- Chromosome Deletion
- DNA Probes
- Female
- Humans
- Male
- Nucleic Acid Hybridization
- Phenotype
- Polymorphism, Restriction Fragment Length
- Sex Chromosome Aberrations
- Sex Determination Analysis
- Translocation, Genetic
- Turner Syndrome
- Y Chromosome