Linkage data for Marfan syndrome and markers on chromosomes 1 and 11.

doi:10.1136/jmg.27.2.82

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Article

Linkage data for Marfan syndrome and markers on chromosomes 1 and 11.

Journal of medical genetics - 1 Feb 1990

de Groote J, Farndon P A, Kilpatrick M V, de Paepe A, Oorthuys J W, Nevin N C, Child A H, Pope F M

Abstract excerpt

Six large families with classical Marfan syndrome were studied using markers on chromosomes 1 and 11. Two of three families tested showed negative scores using D1S7 but a third family gave a positive score (0.92) at theta = 0.1. The other chromosome 1 markers typed (MUCI, NGFB, D1S8) excluded close linkage. Negative lod scores with two chromosome 11q22 markers (D11S84, D11S148) excluded at least 20 cM in this...

Topics

Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 11
Female
Genetic Linkage
Genetic Markers
Humans
Lod Score
Male
Marfan Syndrome
Pedigree
Phenotype

Polymorphism, Restriction Fragment Length

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