Article
Linkage data for Marfan syndrome and markers on chromosomes 1 and 11.
Journal of medical genetics - 1 Feb 1990
de Groote J, Farndon P A, Kilpatrick M V, de Paepe A, Oorthuys J W, Nevin N C, Child A H, Pope F M
Abstract excerpt
Six large families with classical Marfan syndrome were studied using markers on chromosomes 1 and 11. Two of three families tested showed negative scores using D1S7 but a third family gave a positive score (0.92) at theta = 0.1. The other chromosome 1 markers typed (MUCI, NGFB, D1S8) excluded close linkage. Negative lod scores with two chromosome 11q22 markers (D11S84, D11S148) excluded at least 20 cM in this...
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