Article
Isolated human growth hormone deficiency due to the hGH-I gene deletion with (type IA) and without (the Israeli-type) hGH antibody formation during hGH therapy.
Acta endocrinologica - 1 Feb 1990
Nishi Y, Masuda H, Nishimura S, Kihara M, Suwa S, Tachibana K, Takeda M, Okada Y, Matsuda I
Abstract excerpt
Three Japanese patients with isolated growth hormone deficiency from two different families were shown to be homozygous for deletion of the structural gene for human growth hormone (hGH-I gene). These three patients had the same restriction fragment length polymorphism haplotypes. In patient No. 1, the growth rate initially responded well to pituitary human growth hormone, but growth rapidly ceased concomitantly...
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