Article
Isolated human growth hormone deficiency due to the hGH-I gene deletion with (type IA) and without (the Israeli-type) hGH antibody formation during hGH therapy.
Acta endocrinologica - 1 Feb 1990
Nishi Y, Masuda H, Nishimura S, Kihara M, Suwa S, Tachibana K, Takeda M, Okada Y, Matsuda I
Abstract excerpt
Three Japanese patients with isolated growth hormone deficiency from two different families were shown to be homozygous for deletion of the structural gene for human growth hormone (hGH-I gene). These three patients had the same restriction fragment length polymorphism haplotypes. In patient No....
Topics
- Adolescent
- Antibody Formation
- Autoradiography
- Child
- Child, Preschool
- Chromosome Deletion
- DNA
- DNA Restriction Enzymes
- Dwarfism, Pituitary
- Family
- Genes
- Growth Hormone
- Humans
- Male
- Phenotype
- Polymorphism, Restriction Fragment Length