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Article

The locus for the medium-chain acyl-CoA dehydrogenase gene on chromosome 1 is highly polymorphic.

Genomics - 1 Jan 1990

Kidd J R, Matsubara Y, Castiglione C M, Tanaka K, Kidd K K

Abstract excerpt

The gene for medium-chain acyl-CoA dehydrogenase (gene symbol ACADM; enzyme symbol MCAD) has been characterized for restriction fragment length polymorphisms (RFLPs) and mapped by linkage analysis to 4.2 cM from D1S2 and 11.7 cM from PGM1. The three RFLP systems described in detail show significant linkage disequilibrium but define four haplotypes with a PIC of 0.58. This makes ACADM informative for linkage...

Topics

Acyl-CoA Dehydrogenases
Alleles
Blotting, Southern
Chromosomes, Human, Pair 1
Haplotypes
Humans
Lod Score
Phenotype
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1968047
DOI: 10.1016/0888-7543(90)90451-y

Genes

ACADM
PGM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1968047-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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