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Article

Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2009

Mulders Susan A M, van den Broek Walther J A A, Wheeler Thurman M, Croes Huib J E, van Kuik-Romeijn Petra, de Kimpe Sjef J, Furling Denis, Platenburg Gerard J, Gourdon Geneviève, Thornton Charles A, Wieringa Bé, Wansink Derick G

Abstract excerpt

Myotonic dystrophy type 1 (DM1) is caused by toxicity of an expanded, noncoding (CUG)n tract in DM protein kinase (DMPK) transcripts. According to current evidence the long (CUG)n segment is involved in entrapment of muscleblind (Mbnl) proteins in ribonuclear aggregates and stabilized expression of CUG binding protein 1 (CUGBP1), causing aberrant premRNA splicing and associated pathogenesis in DM1 patients. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19667189
DOI: 10.1073/pnas.0905780106
PMCID: PMC2728995

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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