Article
Pinostrobin from Boesenbergia pandurata is an inhibitor of Ca2+-signal-mediated cell-cycle regulation in the yeast Saccharomyces cerevisiae.
Bioscience, biotechnology, and biochemistry - 1 Jul 2009
Wangkangwan Wachirasak, Boonkerd Saipin, Chavasiri Warinthorn, Sukapirom Kasama, Pattanapanyasat Kovit, Kongkathip Ngampong, Miyakawa Tokichi, Yompakdee Chulee
Abstract excerpt
Upon searching plant extracts for inhibitors of the Ca(2+) signaling pathway using the zds1Delta-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on...
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