Article
A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.
Neurogenetics - 1 Feb 2010
Tapanes-Castillo Alexis, Weaver Eli J, Smith Robin P, Kamei Yoshimasa, Caspary Tamara, Hamilton-Nelson Kara L, Slifer Susan H, Martin Eden R, Bixby John L, Lemmon Vance P
Abstract excerpt
Humans with L1 cell adhesion molecule (L1CAM) mutations exhibit X-linked hydrocephalus, as well as other severe neurological disorders. L1-6D mutant mice, which are homozygous for a deletion that removes the sixth immunoglobulin-like domain of L1cam, seldom display hydrocephalus on the 129/Sv background. However, the same L1-6D mutation produces severe hydrocephalus on the C57BL/6J background. To begin to...
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