Article
A quantitative assessment of the burden and distribution of Lisch nodules in adults with neurofibromatosis type 1.
Investigative ophthalmology & visual science - 1 Nov 2009
Boley Sean, Sloan Jennifer L, Pemov Alexander, Stewart Douglas R
Abstract excerpt
PURPOSE: The presence of two or more Lisch nodules (melanocytic hamartomas of the iris) is one of seven diagnostic criteria for neurofibromatosis type 1 (NF1), a common monogenic disorder of dysregulated neurocutaneous growth. The hypothesis that Lisch nodules arise secondary to exposure to ultraviolet (UV) radiation from sunlight was investigated. METHODS: Lisch nodule burden was mapped and quantified in the...
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