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Article

A closely linked DNA marker for facioscapulohumeral disease on chromosome 4q.

Journal of medical genetics - 1 Oct 1991

Upadhyaya M, Lunt P W, Sarfarazi M, Broadhead W, Daniels J, Owen M, Harper P S

Abstract excerpt

Close linkage of a hypervariable DNA probe on chromosome 4q (pH30, locus D4S139) has been found with the locus for facioscapulohumeral disease. Three recombinants were identified in a total of 140 meioses, giving a maximum lod score of 36.77 at a recombination fraction of 0.02. All but two of the families studied proved informative with this probe; all informative families showed evidence of linkage (except one...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 4
DNA
DNA Probes
Genetic Linkage
Genotype
Humans
Lod Score
Meiosis
Muscular Dystrophies
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1941963
DOI: 10.1136/jmg.28.10.665
PMCID: PMC1017052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1941963-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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