Article
10p11.2 to 10q11.2 is a yet unreported region leading to unbalanced chromosomal abnormalities without phenotypic consequences.
Cytogenetic and genome research - 1 Jan 2009
Liehr T, Stumm M, Wegner R D, Bhatt S, Hickmann P, Patsalis P C, Meins M, Morlot S, Klaschka V, Ewers E, Hinreiner S, Mrasek K, Kosyakova N, Cai W W, Cheung S W, Weise A
Abstract excerpt
Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on partial trisomies of chromosome 10 within the pericentromeric region which were detected by standard G banding. Those...
Topics
- Amniocentesis
- Chromosome Aberrations
- Chromosome Banding
- Chromosome Breakage
- Chromosomes, Human, Pair 10
- Comparative Genomic Hybridization
- Female
- Gene Dosage
- Gene Duplication