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Article

A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.

Molecular pharmacology - 1 Jun 2009

Wellhauser Leigh, Kim Chiaw Patrick, Pasyk Stan, Li Canhui, Ramjeesingh Mohabir, Bear Christine E

Abstract excerpt

The deletion of Phe-508 (DeltaPhe508) constitutes the most prevalent of a number of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that cause cystic fibrosis (CF). This mutation leads to CFTR misfolding and retention in the endoplasmic reticulum, as well as impaired c...

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Source

Identifiers

PMID: 19339490
DOI: 10.1124/mol.109.055608

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19339490-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.PMID 19339490Read ↗

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