Article
Association between vitamin D receptor gene polymorphisms and severe chronic periodontitis in a Chinese population.
Journal of periodontology - 1 Apr 2009
Wang Chunxian, Zhao Hongyu, Xiao Limin, Xie Chengjie, Fan Weihua, Sun Shuyu, Xie Baoyi, Zhang Jincai
Abstract excerpt
BACKGROUND: Chronic periodontitis (CP) exhibits inflammation and alveolar bone loss, and severe forms of periodontitis are suggested to have a genetic basis. Vitamin D receptor (VDR) regulates bone metabolism and inflammation-related genes, and single nucleotide polymorphisms (SNPs) in the VDR gene may affect the functional activity of the VDR protein in CP. Therefore, the aim of this study was to investigate the...
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