Article
UGT1A1 haplotype mutation among Asians in Singapore.
Neonatology - 1 Jan 2009
Zhou Y Y, Lee L Y, Ng S Y, Hia C P P, Low K T, Chong Y S, Goh D L M
Abstract excerpt
BACKGROUND: The uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) enzyme is responsible for conjugation of the bilirubin in the liver as well as for drug metabolism. Some of the polymorphisms have been associated with an increased risk of neonatal hyperbilirubinemia which may explain the increased incidence of jaundice in an Asian population as well as exaggerated irinotecan-induced leukopenia. OBJECTIVE:...
Topics
- Asian People
- China
- Cohort Studies
- Ethnicity
- Fetal Blood
- Genetic Predisposition to Disease
- Glucuronosyltransferase
- Haplotypes
- Humans
- Hyperbilirubinemia, Neonatal
- India
- Infant, Newborn
- Mutation
- Polymorphism, Genetic
- Singapore