Article
Prevalence of vitamin D receptor gene polymorphisms FokI and BsmI in Brazilian individuals with type 1 diabetes and their relation to beta-cell autoimmunity and to remaining beta-cell function.
Human immunology - 1 Jun 2009
Mory Denise B, Rocco Eloá R, Miranda Walkíria L, Kasamatsu Teresa, Crispim Felipe, Dib Sérgio A
Abstract excerpt
The effect of the vitamin D receptor (VDR) gene polymorphisms on susceptibility to type 1 diabetes (T1DM) is heterogeneous. Genetic factors may also influence the residual beta-cell function. We studied the frequency of VDR FokI (rs10735810) and BsmI (rs154410) polymorphisms in T1DM and their relationship to beta-cell autoimmunity and residual beta-cell function. We genotyped 189 T1DM (diabetes duration, 7.1 +/-...
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