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Article

MHC class II variation in the endangered European mink Mustela lutreola (L. 1761)--consequences for species conservation.

Immunogenetics - 1 Apr 2009

Becker L, Nieberg C, Jahreis K, Peters E

Abstract excerpt

The polymorphic major histocompatibility complex (MHC) has gained a specific relevance in pathogen resistance and mate choice. Particularly the antigen-binding site (ABS), encoded by exon 2 of the DRB class II gene, exhibits numerous alleles and extensive sequence variations between alleles. A lack of MHC variability has attributed to instances such as bottleneck effects or relaxed selection pressure and has a...

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PMID: 19263000
DOI: 10.1007/s00251-009-0362-2

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