Article
The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules.
Cell - 18 Oct 1991
Legouis R, Hardelin J P, Levilliers J, Claverie J M, Compain S, Wunderle V, Millasseau P, Le Paslier D, Cohen D, Caterina D
Abstract excerpt
Kallmann syndrome associates hypogonadotropic hypogonadism and anosmia and is probably due to a defect in the embryonic migration of olfactory and GnRH-synthesizing neurons. The Kallmann gene had been localized to Xp22.3. In this study 67 kb of genomic DNA, corresponding to a deletion interval co...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Adhesion Molecules
- Cell Line, Transformed
- Chromosome Deletion
- Cloning, Molecular
- Exons
- Extracellular Matrix Proteins
- Fibroblasts
- Fibronectins
- Gene Expression
- Genetic Linkage
- Humans
- Hypogonadism
- Milk Proteins