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Article

The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules.

Cell - 18 Oct 1991

Legouis R, Hardelin J P, Levilliers J, Claverie J M, Compain S, Wunderle V, Millasseau P, Le Paslier D, Cohen D, Caterina D

Abstract excerpt

Kallmann syndrome associates hypogonadotropic hypogonadism and anosmia and is probably due to a defect in the embryonic migration of olfactory and GnRH-synthesizing neurons. The Kallmann gene had been localized to Xp22.3. In this study 67 kb of genomic DNA, corresponding to a deletion interval containing at least part of the Kallmann gene, were sequenced. Two candidate exons, identified by multiparameter computer...

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Identifiers

PMID: 1913827
DOI: 10.1016/0092-8674(91)90193-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules.PMID 1913827Read ↗

A molecular approach to the pathophysiology of the X chromosome-linked Kallmann's syndrome.Semantic proximity Read ↗

A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding moleculesSemantic proximity Read ↗

X chromosome-linked Kallmann syndrome: stop mutations validate the candidate gene.Semantic proximity Read ↗

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Heterogeneity in the mutations responsible for X chromosome-linked Kallmann syndrome.Semantic proximity Read ↗

A recurrent missense mutation in the KAL gene in patients with X-linked Kallmann's syndrome.Semantic proximity Read ↗

Genetic mapping of the Kallmann syndrome and X linked ocular albinism gene loci.Semantic proximity Read ↗

The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching.Semantic proximity Read ↗

Familial Kallmann syndrome: a novel splice acceptor mutation in the KAL gene.Semantic proximity Read ↗

A dinucleotide repeat polymorphism at the Kallmann locus (Xp22.3).Semantic proximity Read ↗

The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons.Semantic proximity Read ↗

KAL, a gene mutated in Kallmann's syndrome, is expressed in the first trimester of human development.Semantic proximity Read ↗

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