Article
Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo.
Circulation - 20 Jan 2009
Conrad Claudius, Niess Hanno, Huss Ralf, Huber Stephan, von Luettichau Irene, Nelson Peter J, Ott Harald C, Jauch Karl-Walter, Bruns Christiane J
Abstract excerpt
BACKGROUND: The importance and therapeutic value of stem cells in lymphangiogenesis are poorly understood. We evaluated the potential of human and murine mesenchymal stem cells (MSCs) to acquire a lymphatic phenotype in vitro and to enhance lymphatic regeneration in vivo. METHODS AND RESULTS: We assessed the lymphendothelial differentiation of human and murine MSCs after induction with supernatant derived from...
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