Recent patents of gene mutation relative to JAK/STAT pathway and their implication in myeloproliferative diseases.

Abstract excerpt

The JAK/STAT pathway plays an important role in the regulation of proliferation and differentiation of hematopoietic cells. The JAK family consists of four different JAK kinasesJAK1, JAK2, JAK3, and tyrosine kinase 2. Recent studies have found that JAK2V617F mutation is present in approximately 90-95% of patients with polycythemia vera (PV), and also in approximately half of those with essential thrombocythemia...

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