Article
An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia.
The American journal of psychiatry - 1 Feb 2009
Turetsky Bruce I, Moberg Paul J
Abstract excerpt
OBJECTIVE: Although olfactory deficits are common in schizophrenia, their underlying pathophysiology remains unknown. Recent evidence has suggested that cAMP signaling may be disrupted in schizophrenia. Since cAMP mediates signal transduction in olfactory receptor neurons, this could contribute to the etiology of observed olfactory deficits. This study was designed to test this hypothesis by determining odor...
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