Article
Molecular prenatal diagnosis of muscular dystrophies in Tunisia and postnatal follow-up role.
Genetic testing - 1 Dec 2008
Siala Olfa, Kammoun Feki Fatma, Louhichi Nacim, Hadj Salem Ikhlass, Gribaa Moez, Elghzel Hatem, Saad Ali, Triki Chahnez, Fakhfakh Faiza
Abstract excerpt
We undertook in this study the first successful prenatal diagnoses of MDC1A and LGMD2C forms in Africa, with a subsequent postnatal clinical follow-up of the newborns. Genetic and molecular studies were performed on cultured amniotic fluid cells after exclusion of maternal cell contamination. Immunofluorescence on the patients' muscle biopsies was performed so as to study the expression of muscular laminins....
Topics
- Adult
- Base Sequence
- Child, Preschool
- DNA Mutational Analysis
- DNA Primers
- Female
- Follow-Up Studies
- Genetic Techniques
- Humans
- Infant
- Infant, Newborn
- Laminin
- Male
- Muscular Dystrophies