Article
Mutations in the Arabidopsis peroxisomal ABC transporter COMATOSE allow differentiation between multiple functions in planta: insights from an allelic series.
Molecular biology of the cell - 1 Jan 2009
Dietrich Daniela, Schmuths Heike, De Marcos Lousa Carine, Baldwin Jocelyn M, Baldwin Stephen A, Baker Alison, Theodoulou Frederica L, Holdsworth Michael J
Abstract excerpt
COMATOSE (CTS), the Arabidopsis homologue of human Adrenoleukodystrophy protein (ALDP), is required for import of substrates for peroxisomal beta-oxidation. A new allelic series and a homology model based on the bacterial ABC transporter, Sav1866, provide novel insights into structure-function relations of ABC subfamily D proteins. In contrast to ALDP, where the majority of mutations result in protein absence...
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