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Article

Structural insight into acute intermittent porphyria.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2009

Song Gaojie, Li Yang, Cheng Chongyun, Zhao Yu, Gao Ang, Zhang Rongguang, Joachimiak Andrzej, Shaw Neil, Liu Zhi-Jie

Abstract excerpt

Acute intermittent porphyria (AIP), an inherited disease of heme biosynthesis, is one of the most common types of porphyria. Reduced activity of the enzyme porphobilinogen deaminase (PBGD), which catalyzes the sequential condensation of 4 molecules of porphobilinogen to yield preuroporphyrinogen, has been linked to the symptoms of AIP. We have determined the 3-dimensional structure of human PBGD at 2.2 A...

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Share to Crystallography, X-Ray

Share to Hydrogen Bonding

Share to Hydroxymethylbilane Synthase

Share to Porphyria, Acute Intermittent

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Identifiers

PMID: 18936296
DOI: 10.1096/fj.08-115469

Genes

AIP

Provenance

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