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Article

Isofagomine induced stabilization of glucocerebrosidase.

Chembiochem : a European journal of chemical biology - 3 Nov 2008

Kornhaber Gregory J, Tropak Michael B, Maegawa Gustavo H, Tuske Steven J, Coales Stephen J, Mahuran Don J, Hamuro Yoshitomo

Abstract excerpt

Structurally destabilizing mutations in acid beta-glucosidase (GCase) can result in Gaucher disease (GD). The iminosugar isofagomine (IFG), a competitive inhibitor and a potential pharmacological chaperone of GCase, is currently undergoing clinical evaluation for the treatment of GD. An X-ray crystallographic study of the GCase-IFG complex revealed a hydrogen bonding network between IFG and certain active site...

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Identifiers

PMID: 18932186
DOI: 10.1002/cbic.200800249
PMCID: PMC2910746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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