Article
Gene cassettes encoding resistance to quaternary ammonium compounds: a role in the origin of clinical class 1 integrons?
16 Oct 2008
Abstract excerpt
DNA sequencing, phylogenetic and mapping studies suggest that the class 1 integron found in pathogens arose when one member of the diverse family of environmental class 1 integrons became embedded into a Tn402 transposon. However, the timing of this event and the selective forces that first fixed the newly formed element in a bacterial lineage are still unknown. Biocides have a longer use in clinical practice...
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