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Article

Lithium's antisuicidal efficacy: elucidation of neurobiological targets using endophenotype strategies.

Annual review of pharmacology and toxicology - 1 Jan 2009

Kovacsics Colleen E, Gottesman Irving I, Gould Todd D

Abstract excerpt

Lithium used as a drug treatment for major mental disorders such as bipolar disorder and depression is effective in reducing the risk of both attempted and completed suicide. However, the mechanisms underlying lithium's antisuicidal actions are not yet known, limiting the development of novel lithium-mimetic compounds that may help reduce suicide risk with fewer undesirable side effects. Suicide is a complex...

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Identifiers

PMID: 18834309
DOI: 10.1146/annurev.pharmtox.011008.145557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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