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Article

Non-genomic effects of sex hormones on CLC-1 may contribute to gender differences in myotonia congenita.

Neuromuscular disorders : NMD - 1 Nov 2008

Fialho Doreen, Kullmann Dimitri M, Hanna Michael G, Schorge Stephanie

Abstract excerpt

Myotonia congenita is caused by mutations in the voltage-gated chloride channel ClC-1. It is more severe in men than women and often worsens during pregnancy, but the basis for these gender differences is not known. We show here that both testosterone and progesterone rapidly and reversibly inhib...

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Identifiers

PMID: 18815035
DOI: 10.1016/j.nmd.2008.07.004

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CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18815035-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Non-genomic effects of sex hormones on CLC-1 may contribute to gender differences in myotonia congenita.PMID 18815035Read ↗

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