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Article

Breakthrough in penicillin resistance? Streptococcus pneumoniae isolates with penicillin/cefotaxime MICs of 16 mg/L and their genotypic and geographical relatedness.

The Journal of antimicrobial chemotherapy - 1 Dec 2008

Soriano Francisco, Cafini Fabio, Aguilar Lorenzo, Tarragó David, Alou Luis, Giménez Maria-Jose, Gracia Matilde, Ponte Maria-Carmen, Leu Denisa, Pana Marina, Letowska Iwona, Fenoll Asuncion

Abstract excerpt

OBJECTIVES: To phenotypically and genotypically characterize 11 strains (isolated in four different centres) exhibiting penicillin MIC of 8-32 mg/L among isolates of the SPICE project. Nine isolates were from Romania (9/162; 5.56%) and two from Poland (2/305; 0.66%). METHODS: In vitro susceptibility was determined in triplicate by microdilution (CLSI guidelines), and additionally, MICs of penicillin, cefotaxime...

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PMID: 18799472
DOI: 10.1093/jac/dkn392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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